The player faces a global threat of bioterrorism in story campaigns that focus on three characters: Leon Kennedy engaged into an investigation of the epidemic in the Tall Oaks, U.S.A., Chris Redfield in pursuit of a mysterious woman, who caused death of many people in his department, and Jake Muller, a mercenary, son of Albert Wesker – who was the main antagonist of the previous games.
RE6 does not follow the direction set by the two previous games, so in result zombies and the mysterious virus make a return.