Also don't start collecting or carrying crap around. keep in mind that the game saves the location of every item in the cell you enter.
The game forgets that it was there and you'll see your savegame size reducing. When you enter a new area get every crap item and sell it asap (Not in luck圓8s store. Doing this should ease some of your Frame-Rate and freezing issues. I know this works in the Elder Scroll games, though I'm not sure about Fallout but if you have any junk you want to ditch, then put it all in a corpse and wait for it to disappear.
